For a list of publications on pubmed, click here:
53. Delyea C.,* Forster M.,* Luo S.Y.,* Julien O., Bhavsar A.P. (2024) "The Salmonella effector SspH2 facilitates spatially selective ubiquitination of NOD1 to enhance inflammatory signaling" Biochemistry (in press)
52. Gomez-Cardona E.,* Dehkordi M.H.,* Van Baar K., Vitkauskaite A., Julien O.,* and Fearnhead H.O.* (2024) "An atlas of caspase cleavage events in differentiating muscle cells" Protein Science. 33:e5156
51. Pirayeshfard L.,* Luo S.Y.,* Githaka J.M., Saini A., Touret N., Goping I.S.,* and Julien O.* (2024) "Comparing the BAD protein interactomes in 2D and 3D cell culture using proximity labeling." Journal of Proteome Research. 23:3433-3443
50. Eskandari-Sedighi G., Crichton M., Zia S., Gomez-Cardona E., Cortez L.M., Patel Z.H, Takahashi-Yamashiro K., St. Laurent C.D., Sidhu G., Sarkar S., Aghanya V., Sim V.L., Tan Q., Julien O., Plemel J.R., Macauley M.S. (2024) "Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice" Molecular Neurodegeneration. 19:42
49. Beauchamp E., Gamma J.M., Cromwell C.R., Moussa E.W, Pain R., Kostiuk M.A., Acevedo-Morantes C., Iyer A., Yap M., Vincent K.M., Postovit L.M., Julien O., Hubbard B.P., Mackey J.R., Berthiaume L.G. (2024) "Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition" J. Translational Medicine. 22:431
48. Hartley B., Bassiouni W., Roczkowsky A., Fahlman R., Schulz R., and Julien O. (2024) "N-terminomic identification of intracellular MMP-2 substrates in cardiac tissue" Journal of Proteome Research. (in press)
47. Alzahrani K.R., Gomez-Cardona E., Gandhi V., Palikhe N.S., Laratta C., Julien O., and Vliagoftis H. (2024) "German cockroach extract prevents IL-13-induced CCL26 expression in airway epithelial cells through IL-13 degradation" FASEB J. 2024 Mar 15:e23531
46. Mahabadi H.M., Lin Y.C.J., Ogando N.S., Moussa E.W., Mohammadzadeh N., Julien O., Alto N., Noyce R.S., Evans D.H., Power C. (2024) "Monkeypox virus infection of human astrocytes causes gasdermin B cleavage and pyroptosis" Proc. Natl. Acad. Sci. U.S.A. 121:e2315653121
45. Hartley B., Bassiouni W., Roczkowsky A., Fahlman R., Schulz R., and Julien O. (2024) "Data-Independent Acquisition Proteomics and N-Terminomics Methods Reveal Alterations in Mitochondrial Function and Metabolism in Ischemic-Reperfused Hearts" Journal of Proteome Research. 23:844-856
44. Gomez-Cardona E., Eskandari-Sedighi G., Fahlman R., Westaway D., and Julien O. (2024) "Application of N-terminal labeling methods provide novel insights into endoproteolysis of the prion protein in vivo" ACS Chemical Neuroscience. 15:134-146
43. Pollock N.M., Fernandes J.P., Woodfield J., Moussa E., Hlavay B., Branton W.G., Wuest M., Mohammadzadeh N., Schmitt L., Plemel J.R., Julien O., Wuest F., Power C. (2024) "Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis" Brain Behavior and Immunity 115:374-393
42. Sun K.T., Patel T., Kang S.G., Yarahmady A., Srinivasan M., Julien O., Heras J., Mok S.A. (2023) "Disease associated mutations in tau encode for changes in aggregate structure conformation" ACS Chemical Neuroscience 14:4282-4297
41. Hartley B., Bassiouni W., Schulz R., Julien O. (2023) "The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury" (review) Basic Research in Cardiology 118, 38
40. Chen S.A., Arutyunova E., Lu J., Khan M.B., Rut W., Zmudzinski M., Shahbaz S., Iyyathurai J., Moussa E.W., Turner Z., Bai B., Lamer T., Nieman J.A., Vederas J.C., Julien O., Drag M., Elahi S., Young H.S., and Lemieux J.M. (2023) "SARS-CoV-2 Mpro protease variants of concern display altered viral substrate and cell host target Gal8 processing but retain sensitivity towards antivirals" ACS Central Science 9:696-708
39. Luo S.Y., Moussa E., Lopez-Orozco J., Felix-Lopez A., Ishida R., Fayad N., Gomez-Cardona E., Wang H., Wilson J., Kumar A., Hobman T. and Julien O. (2023) "Identification of Human Host Substrates of the SARS-CoV‑2 Mpro and PLpro Using Subtiligase N‑Terminomics" ACS Infectious diseases 9:749-61
38. Wang H. and Julien O. (2023)
"CaspSites: A Database and Web Application for Experimentally Observed Human Caspase Substrates Using N-Terminomics"
Journal of Proteome Research 22:454-461
www.caspsites.org
37. Aujla P.K., Hu M., Hartley B., Kranrod J., Viveiros A., Kilic T., Owen C.A., Oudit G.Y., Seubert J.M., Julien O., Kassiri Z. (2022) "Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway." Hypertension 80:97-110
36. Ishida R., Cole J., Lopez-Orozco J., Fayad N., Felix-Lopez A., Elaish M., Luo S.Y., Julien O., Kumar A., Hobman T.C. (2021) "Mayaro Virus Non-Structural Protein 2 Circumvents the Induction of Interferon in Part by Depleting Host Transcription Initiation Factor IIE Subunit 2." Cells 10:3510
35. Araya L.E.,* Soni I.,* Hardy J.A., Julien O. (2021) "Deorphanizing caspase‑3 and caspase‑9 substrates in and out of apoptosis with deep substrate Profiling." ACS Chem. Biol. 16:2280-2296
34. Wang L.,* Main K.,* Wang H., Julien O.,* and Dufour A.* (2021) "Biochemical Tools for Tracking Proteolysis." J. Proteome Res. 20:5264-5279
33. Kerek E.M., Yoon K.H., Luo S.Y., Chen J., Valencia R., Julien O., Waskiewicz A.J., Hubbard B.P. (2020) "A conserved acetylation switch enables pharmacological control of tubby-like protein stability." J. Biol. Chem. 296:100073
32. Daude N., Kim C., Kang S.G., Eskandari-Sedighi G., Haldiman T., Yang J., Fleck S.C., Gomez-Cardona E., Han Z.Z., Borrego-Ecija S., Wohlgemuth S., Julien O., Wille H, Molina-Porcel L, Gelpi E, Safar JG, Westaway D. (2020) "Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation." Acta Neuropathol. 139:1045-1070
31. Roczkowsky A., Chan B.Y.H., Lee T.Y.T., Mahmud Z., Hartley B., Julien O., Armanious G., Young H.S., Schulz R. (2019) "Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischemia-reperfusion injury." Cardiovasc. Res. cvz207
30. Luo S.Y.,* Araya L.E.* and Julien O. (2019) "Protease substrate identification using N-terminomics." ACS Chem. Biol. 14:2361-2371
29. Freilich R., Betegon M., Tse E., Mok S.A., Julien O., Agard D.A., Southworth D., Takeuchi K., and Gestwicki J.E. (2018) "Competing Protein-Protein Interactions Regulate Binding of Hsp27 to Tau." Nat. Commun. 9:4563
28. Hill M.E., Kumar A., Wells J.A., Hobman T.C., Julien O., Hardy J.A. (2018) "The unique cofactor region of Zika virus NS2B-NS3 protease facilitates cleavage of key host proteins." ACS Chem. Biol. 13:2398-2405
27. Mok S.A., Condello C., Gillies A., Freilich R., Oroz J., Kadavath H., Julien O., Assimon V., Rauch J., Dunyak B., Lee J., Tsai F., Wilson M., Zweckstetter M., Dickey C., and Gestwicki J. (2018) "Mapping Interactions with the Chaperone Network Reveals Proteostasis Factors that Protect Against Tau Aggregation." Nat. Struct. Mol. Biol. 25:384-393
26. Pollock S., Hu A., Mou Y., Martinko A., Julien O., Hornsby M., Ploder L., Adams J., Muschen M., Sidhu S.S., Moffat J, Geng H., and Wells J.A. (2018) "Highly multiplexed and quantitative cell surface protein profiling using genetically barcoded antibodies." Proc. Natl. Acad. Sci. U.S.A. 115:2836-2841
25. Martinko A.J., Truillet C., Julien O, Diaz J., Horlbeck M.A., Whiteley G., Blonder J., Weissman J.S., Bandyopadhyay S., Evans M., and Wells J.A. (2018) "Targeting RAS driven human cancer cells with antibodies to upregulated and essential cell-surface proteins." eLife e31098
24. Srinivasan S.R., Cesa L.C., Li X., Julien O., Zhuang M., Shao H., Chung J., Maillard I., Wells J.A., Duckett C.S., Gestwicki J.E. (2018) "Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades." Mol Cancer Res. 16:58-68
23. Julien O. and Wells J.A. (2017) "Caspases and their substrates" Cell Death Differ. 24:1380-1389
22. Tran H.L., Lexa K.W., Julien O., Young T.S., Walsh C.T., Jacobson M.P., and Wells J.A. (2017) "SAR and molecular mechanics reveal the importance of ring entropy in the biosynthesis and activity of a natural product" J. Am. Chem. Soc. 139:2541-2544
21. Calvo S.E., Julien O., Clauser K.R., Shen H., Kamer K.J., Wells J.A. Mootha V.K. (2017) "Comparative analysis of mitochondrial N-termini from mouse, human, and yeast" Mol. Cell. Proteomics. 16:512-523
20. Seaman J.E., Julien O., Lee P.S., Rettenmaier T.J., Thomsen N.D., Wells J.A. (2016) "Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues" Cell Death Differ. 23:1717-1726
19. Hill, M.E., MacPherson D.J., Wu P. Julien O., Wells J.A., and Hardy J.A. (2016) "Reprogramming Caspase‑7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition." ACS Chem. Biol. 11:1603-1612
18. Julien O., Zhuang M., Wiita A.P., O’Donoghue A.J., Knudsen G.M., Craik C.S., and Wells J.A. (2016) "Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles." Proc. Natl. Acad. Sci. U.S.A. 113:E2001-2010
17. Lee D., Kraus A., Groenendyk J., Prins D., Liu W.-X., Li H.-D., Julien O., Touret N., Sykes B. and Michalak M. (2015) "UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum." J. Biol. Chem. 290:5725-5738.
16. Julien O., Kampmann M., Bassik M.C., Zorn J.A., Venditto V.J., Shimbo K., Agard N.J., Shimada K., Rheingold A.L., Stockwell B.R., Weissman J.S., and Wells J.A. (2014) "Unraveling the mechanism of cell death induced by chemical fibrils." Nat. Chem. Biol. 10:969-976
15. Morgan C.W., Julien O., Unger E.K., Shah N.M., Wells J.A. (2014) "Turning on caspases with genetics and small molecules." Methods Enzymol. 2014;544:179-213
14. Pineda Sanabria S.E., Julien O., Sykes B.D. (2014) "A versatile cardiac troponin chimera for muscle protein structural biology and drug discovery." ACS Chem. Biol. 9:2121-2130.
13. Wiita A.P., Ziv E., Wiita P.J., Urisman A., Julien O., Burlingame A.L., Weissman J.S., and Wells J.A. (2013) "Global cellular response to chemotherapy-induced apoptosis." eLife. 2:e01236
12. Crawford E.D., Seaman J.E., Agard N., Hsu G.W., Julien O., Mahrus S., Nguyen H., Shimbo K., Yoshihara H., Zhuang M., Chalkley R.J., Wells J.A. (2013) "The DegraBase: a database of proteolysis in healthy and apoptotic human cells." Mol. Cell. Proteomics 12, 813-824
11. Julien O., Wang G., Jonckheer A., Engelborghs Y., and Sykes B. D. (2012) "Tryptophan side chain conformers monitored by NMR and time-resolved fluorescence spectroscopies." Proteins: Structure, Function, and Bioinformatics. 80(1):239-245.
10. Julien O., Chatterjee S., Bjorndahl T.C., Sweeting B., Acharya S., Semenchenko V., Chakrabartty A., Pai E.F, Wishart D.S., Sykes B.D. and Cashman N.R. (2011) "Relative and Regional Stabilities of the Hamster, Mouse, Rabbit, and Bovine Prion Proteins toward Urea Unfolding Assessed by Nuclear Magnetic Resonance and Circular Dichroism Spectroscopies." Biochemistry. 50(35):7536-7545.
9. Julien O., Mercier P., Allen C., Fisette O., Ramos C.H., Lagüe P., Blumenschein T.M.A., and Sykes B.D. (2011) "Is There Nascent Structure in the Intrinsically Disordered Region of Troponin I?" Proteins: Structure, Function, and Bioinformatics. 79(4):1240-1250.
8. Julien O., Beadle J.R., Magee W.C., Chatterjee S., Hostetler K.Y., Evans D.H., Sykes B.D. (2011) "Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir." Journal of the American Chemical Society. 133(7):2264-2274.
7. Julien O., Graether S.P., Sykes B.D. (2009) "Monitoring prion protein stability by NMR." Journal of Toxicology and Environmental Health.
6. Julien O., Chatterjee S., Graether S. P., Thiessen A., Sykes B. D. (2009) "Differential stability of the bovine prion protein upon urea unfolding." Protein Science. 18:2172-2182.
5. Julien O., Mercier P., Crane M. L., Sykes B. D. (2009) "The effect of the co-solvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C." Protein Science. 18:1165-1174.
4. Julien O., Mercier P., Spyracopoulos L., Corrie J.E.T., Sykes B.D. (2008) "NMR Studies of the Dynamics of a Bifunctional Rhodamine Probe Attached to Troponin C." Journal of the American Chemical Society. 130:2602-2609
3. Julien O., Sun Y.-B, Wang X., Lindhout D. A., Thiessen A., Irving M., Sykes B.D. (2008) "Tryptophan Mutants of Cardiac Troponin C: Correlation Between 3D Structure, Troponin I Affinity, and in situ Activity." Biochemistry. 47:597-606.
2. Julien O., Sun Y.-B., Knowles A.C., Brandmeier B.D., Dale R.E., Trentham D.R., Corrie J.E.T., Sykes B.D., Irving M. (2007) "Towards Protein Structure in situ: Comparison of Two Bifunctional Rhodamine Adducts of Troponin C." Biophysical Journal. 93:1008-1020
1. Julien O., Gignac I., Hutton A., Yee A., Arrowsmith C.H., Gagné S.M. (2006) "MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like Repeats." J. Biomol. NMR. 35:149-154.