Publications

For a list of publications on pubmed, click here:

2024

53. Delyea C.,* Forster M.,* Luo S.Y.,* Julien O., Bhavsar A.P. (2024) "The Salmonella effector SspH2 facilitates spatially selective ubiquitination of NOD1 to enhance inflammatory signaling" Biochemistry (in press)

52. Gomez-Cardona E.,* Dehkordi M.H.,* Van Baar K., Vitkauskaite A., Julien O.,* and Fearnhead H.O.* (2024) "An atlas of caspase cleavage events in differentiating muscle cells" Protein Science. 33:e5156

51. Pirayeshfard L.,* Luo S.Y.,* Githaka J.M., Saini A., Touret N., Goping I.S.,* and Julien O.* (2024) "Comparing the BAD protein interactomes in 2D and 3D cell culture using proximity labeling." Journal of Proteome Research. 23:3433-3443

50. Eskandari-Sedighi G., Crichton M., Zia S., Gomez-Cardona E., Cortez L.M., Patel Z.H, Takahashi-Yamashiro K., St. Laurent C.D., Sidhu G., Sarkar S., Aghanya V., Sim V.L., Tan Q., Julien O., Plemel J.R., Macauley M.S. (2024) "Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice" Molecular Neurodegeneration. 19:42

49. Beauchamp E., Gamma J.M., Cromwell C.R., Moussa E.W, Pain R., Kostiuk M.A., Acevedo-Morantes C., Iyer A., Yap M., Vincent K.M., Postovit L.M., Julien O., Hubbard B.P., Mackey J.R., Berthiaume L.G. (2024) "Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition" J. Translational Medicine. 22:431

48. Hartley B., Bassiouni W., Roczkowsky A., Fahlman R., Schulz R., and Julien O. (2024) "N-terminomic identification of intracellular MMP-2 substrates in cardiac tissue" Journal of Proteome Research. (in press)

47. Alzahrani K.R., Gomez-Cardona E., Gandhi V., Palikhe N.S., Laratta C., Julien O., and Vliagoftis H. (2024) "German cockroach extract prevents IL-13-induced CCL26 expression in airway epithelial cells through IL-13 degradation" FASEB J. 2024 Mar 15:e23531

46. Mahabadi H.M., Lin Y.C.J., Ogando N.S., Moussa E.W., Mohammadzadeh N., Julien O., Alto N., Noyce R.S., Evans D.H., Power C. (2024) "Monkeypox virus infection of human astrocytes causes gasdermin B cleavage and pyroptosis" Proc. Natl. Acad. Sci. U.S.A. 121:e2315653121

45. Hartley B., Bassiouni W., Roczkowsky A., Fahlman R., Schulz R., and Julien O. (2024) "Data-Independent Acquisition Proteomics and N-Terminomics Methods Reveal Alterations in Mitochondrial Function and Metabolism in Ischemic-Reperfused Hearts" Journal of Proteome Research. 23:844-856

44. Gomez-Cardona E., Eskandari-Sedighi G., Fahlman R., Westaway D., and Julien O. (2024) "Application of N-terminal labeling methods provide novel insights into endoproteolysis of the prion protein in vivo" ACS Chemical Neuroscience. 15:134-146

43. Pollock N.M., Fernandes J.P., Woodfield J., Moussa E., Hlavay B., Branton W.G., Wuest M., Mohammadzadeh N., Schmitt L., Plemel J.R., Julien O., Wuest F., Power C. (2024) "Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis" Brain Behavior and Immunity 115:374-393

2023

42. Sun K.T., Patel T., Kang S.G., Yarahmady A., Srinivasan M., Julien O., Heras J., Mok S.A. (2023) "Disease associated mutations in tau encode for changes in aggregate structure conformation" ACS Chemical Neuroscience 14:4282-4297

41. Hartley B., Bassiouni W., Schulz R., Julien O. (2023) "The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury" (review) Basic Research in Cardiology 118, 38

40. Chen S.A., Arutyunova E., Lu J., Khan M.B., Rut W., Zmudzinski M., Shahbaz S., Iyyathurai J., Moussa E.W., Turner Z., Bai B., Lamer T., Nieman J.A., Vederas J.C., Julien O., Drag M., Elahi S., Young H.S., and Lemieux J.M. (2023) "SARS-CoV-2 Mpro protease variants of concern display altered viral substrate and cell host target Gal8 processing but retain sensitivity towards antivirals" ACS Central Science 9:696-708

39. Luo S.Y., Moussa E., Lopez-Orozco J., Felix-Lopez A., Ishida R., Fayad N., Gomez-Cardona E., Wang H., Wilson J., Kumar A., Hobman T. and Julien O. (2023) "Identification of Human Host Substrates of the SARS-CoV‑2 Mpro and PLpro Using Subtiligase N‑Terminomics" ACS Infectious diseases 9:749-61

38. Wang H. and Julien O. (2023) "CaspSites: A Database and Web Application for Experimentally Observed Human Caspase Substrates Using N-Terminomics" Journal of Proteome Research 22:454-461
www.caspsites.org

2022

37. Aujla P.K., Hu M., Hartley B., Kranrod J., Viveiros A., Kilic T., Owen C.A., Oudit G.Y., Seubert J.M., Julien O., Kassiri Z. (2022) "Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway." Hypertension 80:97-110

2021

36. Ishida R., Cole J., Lopez-Orozco J., Fayad N., Felix-Lopez A., Elaish M., Luo S.Y., Julien O., Kumar A., Hobman T.C. (2021) "Mayaro Virus Non-Structural Protein 2 Circumvents the Induction of Interferon in Part by Depleting Host Transcription Initiation Factor IIE Subunit 2." Cells 10:3510

35. Araya L.E.,* Soni I.,* Hardy J.A., Julien O. (2021) "Deorphanizing caspase‑3 and caspase‑9 substrates in and out of apoptosis with deep substrate Profiling." ACS Chem. Biol. 16:2280-2296

34. Wang L.,* Main K.,* Wang H., Julien O.,* and Dufour A.* (2021) "Biochemical Tools for Tracking Proteolysis." J. Proteome Res. 20:5264-5279

2020

33. Kerek E.M., Yoon K.H., Luo S.Y., Chen J., Valencia R., Julien O., Waskiewicz A.J., Hubbard B.P. (2020) "A conserved acetylation switch enables pharmacological control of tubby-like protein stability." J. Biol. Chem. 296:100073

32. Daude N., Kim C., Kang S.G., Eskandari-Sedighi G., Haldiman T., Yang J., Fleck S.C., Gomez-Cardona E., Han Z.Z., Borrego-Ecija S., Wohlgemuth S., Julien O., Wille H, Molina-Porcel L, Gelpi E, Safar JG, Westaway D. (2020) "Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation." Acta Neuropathol. 139:1045-1070

2019

31. Roczkowsky A., Chan B.Y.H., Lee T.Y.T., Mahmud Z., Hartley B., Julien O., Armanious G., Young H.S., Schulz R. (2019) "Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischemia-reperfusion injury." Cardiovasc. Res. cvz207

30. Luo S.Y.,* Araya L.E.* and Julien O. (2019) "Protease substrate identification using N-terminomics." ACS Chem. Biol. 14:2361-2371

2018

29. Freilich R., Betegon M., Tse E., Mok S.A., Julien O., Agard D.A., Southworth D., Takeuchi K., and Gestwicki J.E. (2018) "Competing Protein-Protein Interactions Regulate Binding of Hsp27 to Tau." Nat. Commun. 9:4563

28. Hill M.E., Kumar A., Wells J.A., Hobman T.C., Julien O., Hardy J.A. (2018) "The unique cofactor region of Zika virus NS2B-NS3 protease facilitates cleavage of key host proteins." ACS Chem. Biol. 13:2398-2405

27. Mok S.A., Condello C., Gillies A., Freilich R., Oroz J., Kadavath H., Julien O., Assimon V., Rauch J., Dunyak B., Lee J., Tsai F., Wilson M., Zweckstetter M., Dickey C., and Gestwicki J. (2018) "Mapping Interactions with the Chaperone Network Reveals Proteostasis Factors that Protect Against Tau Aggregation." Nat. Struct. Mol. Biol. 25:384-393

26. Pollock S., Hu A., Mou Y., Martinko A., Julien O., Hornsby M., Ploder L., Adams J., Muschen M., Sidhu S.S., Moffat J, Geng H., and Wells J.A. (2018) "Highly multiplexed and quantitative cell surface protein profiling using genetically barcoded antibodies." Proc. Natl. Acad. Sci. U.S.A. 115:2836-2841

25. Martinko A.J., Truillet C., Julien O, Diaz J., Horlbeck M.A., Whiteley G., Blonder J., Weissman J.S., Bandyopadhyay S., Evans M., and Wells J.A. (2018) "Targeting RAS driven human cancer cells with antibodies to upregulated and essential cell-surface proteins." eLife e31098

24. Srinivasan S.R., Cesa L.C., Li X., Julien O., Zhuang M., Shao H., Chung J., Maillard I., Wells J.A., Duckett C.S., Gestwicki J.E. (2018) "Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades." Mol Cancer Res. 16:58-68

2017

23. Julien O. and Wells J.A. (2017) "Caspases and their substrates" Cell Death Differ. 24:1380-1389

22. Tran H.L., Lexa K.W., Julien O., Young T.S., Walsh C.T., Jacobson M.P., and Wells J.A. (2017) "SAR and molecular mechanics reveal the importance of ring entropy in the biosynthesis and activity of a natural product" J. Am. Chem. Soc. 139:2541-2544

21. Calvo S.E., Julien O., Clauser K.R., Shen H., Kamer K.J., Wells J.A. Mootha V.K. (2017) "Comparative analysis of mitochondrial N-termini from mouse, human, and yeast" Mol. Cell. Proteomics. 16:512-523

2016

20. Seaman J.E., Julien O., Lee P.S., Rettenmaier T.J., Thomsen N.D., Wells J.A. (2016) "Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues" Cell Death Differ. 23:1717-1726

19. Hill, M.E., MacPherson D.J., Wu P. Julien O., Wells J.A., and Hardy J.A. (2016) "Reprogramming Caspase‑7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition." ACS Chem. Biol. 11:1603-1612

18. Julien O., Zhuang M., Wiita A.P., O’Donoghue A.J., Knudsen G.M., Craik C.S., and Wells J.A. (2016) "Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles." Proc. Natl. Acad. Sci. U.S.A. 113:E2001-2010

2015

17. Lee D., Kraus A., Groenendyk J., Prins D., Liu W.-X., Li H.-D., Julien O., Touret N., Sykes B. and Michalak M. (2015) "UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum." J. Biol. Chem. 290:5725-5738.

2014

16. Julien O., Kampmann M., Bassik M.C., Zorn J.A., Venditto V.J., Shimbo K., Agard N.J., Shimada K., Rheingold A.L., Stockwell B.R., Weissman J.S., and Wells J.A. (2014) "Unraveling the mechanism of cell death induced by chemical fibrils." Nat. Chem. Biol. 10:969-976

15. Morgan C.W., Julien O., Unger E.K., Shah N.M., Wells J.A. (2014) "Turning on caspases with genetics and small molecules." Methods Enzymol. 2014;544:179-213

14. Pineda Sanabria S.E., Julien O., Sykes B.D. (2014) "A versatile cardiac troponin chimera for muscle protein structural biology and drug discovery." ACS Chem. Biol. 9:2121-2130.

2013

13. Wiita A.P., Ziv E., Wiita P.J., Urisman A., Julien O., Burlingame A.L., Weissman J.S., and Wells J.A. (2013) "Global cellular response to chemotherapy-induced apoptosis." eLife. 2:e01236

12. Crawford E.D., Seaman J.E., Agard N., Hsu G.W., Julien O., Mahrus S., Nguyen H., Shimbo K., Yoshihara H., Zhuang M., Chalkley R.J., Wells J.A. (2013) "The DegraBase: a database of proteolysis in healthy and apoptotic human cells." Mol. Cell. Proteomics 12, 813-824

2012

11. Julien O., Wang G., Jonckheer A., Engelborghs Y., and Sykes B. D. (2012) "Tryptophan side chain conformers monitored by NMR and time-resolved fluorescence spectroscopies." Proteins: Structure, Function, and Bioinformatics. 80(1):239-245.

2011

10. Julien O., Chatterjee S., Bjorndahl T.C., Sweeting B., Acharya S., Semenchenko V., Chakrabartty A., Pai E.F, Wishart D.S., Sykes B.D. and Cashman N.R. (2011) "Relative and Regional Stabilities of the Hamster, Mouse, Rabbit, and Bovine Prion Proteins toward Urea Unfolding Assessed by Nuclear Magnetic Resonance and Circular Dichroism Spectroscopies." Biochemistry. 50(35):7536-7545.

9. Julien O., Mercier P., Allen C., Fisette O., Ramos C.H., Lagüe P., Blumenschein T.M.A., and Sykes B.D. (2011) "Is There Nascent Structure in the Intrinsically Disordered Region of Troponin I?" Proteins: Structure, Function, and Bioinformatics. 79(4):1240-1250.

8. Julien O., Beadle J.R., Magee W.C., Chatterjee S., Hostetler K.Y., Evans D.H., Sykes B.D. (2011) "Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir." Journal of the American Chemical Society. 133(7):2264-2274.

2009

7. Julien O., Graether S.P., Sykes B.D. (2009) "Monitoring prion protein stability by NMR." Journal of Toxicology and Environmental Health.

6. Julien O., Chatterjee S., Graether S. P., Thiessen A., Sykes B. D. (2009) "Differential stability of the bovine prion protein upon urea unfolding." Protein Science. 18:2172-2182.

5. Julien O., Mercier P., Crane M. L., Sykes B. D. (2009) "The effect of the co-solvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C." Protein Science. 18:1165-1174.

2008

4. Julien O., Mercier P., Spyracopoulos L., Corrie J.E.T., Sykes B.D. (2008) "NMR Studies of the Dynamics of a Bifunctional Rhodamine Probe Attached to Troponin C." Journal of the American Chemical Society. 130:2602-2609

3. Julien O., Sun Y.-B, Wang X., Lindhout D. A., Thiessen A., Irving M., Sykes B.D. (2008) "Tryptophan Mutants of Cardiac Troponin C: Correlation Between 3D Structure, Troponin I Affinity, and in situ Activity." Biochemistry. 47:597-606.

2007

2. Julien O., Sun Y.-B., Knowles A.C., Brandmeier B.D., Dale R.E., Trentham D.R., Corrie J.E.T., Sykes B.D., Irving M. (2007) "Towards Protein Structure in situ: Comparison of Two Bifunctional Rhodamine Adducts of Troponin C." Biophysical Journal. 93:1008-1020

2006

1. Julien O., Gignac I., Hutton A., Yee A., Arrowsmith C.H., Gagné S.M. (2006) "MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like Repeats." J. Biomol. NMR. 35:149-154.