Publications

For a list of publications on pubmed, click here:

Postdoctoral work

23. Julien O. and Wells J.A. (2017) "Caspases and their substrates" Cell Death Differ. (in press)

22. Tran H.L., Lexa K.W., Julien O., Young T.S., Walsh C.T., Jacobson M.P., and Wells J.A. (2017) "SAR and molecular mechanics reveal the importance of ring entropy in the biosynthesis and activity of a natural product" J. Am. Chem. Soc. (in press)

21. Calvo S.E., Julien O., Clauser K.R., Shen H., Kamer K.J., Wells J.A. Mootha V.K. (2017) "Comparative analysis of mitochondrial N-termini from mouse, human, and yeast" Mol. Cell. Proteomics. (in press)

20. Seaman J.E., Julien O., Lee P.S., Rettenmaier T.J., Thomsen N.D., Wells J.A. (2016) "Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues" Cell Death Differ. 23:1717-1726

19. Hill, M.E., MacPherson D.J., Wu P. Julien O., Wells J.A., and Hardy J.A. (2016) "Reprogramming Caspase‑7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition." ACS Chem. Biol. 11:1603-1612

18. Julien O., Zhuang M., Wiita A.P., O’Donoghue A.J., Knudsen G.M., Craik C.S., and Wells J.A. (2016) "Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles." Proc. Natl. Acad. Sci. U.S.A. 113:E2001-2010

17. Julien O., Kampmann M., Bassik M.C., Zorn J.A., Venditto V.J., Shimbo K., Agard N.J., Shimada K., Rheingold A.L., Stockwell B.R., Weissman J.S., and Wells J.A. (2014) "Unraveling the mechanism of cell death induced by chemical fibrils." Nat. Chem. Biol. 10:969-976

16. Morgan C.W., Julien O., Unger E.K., Shah N.M., Wells J.A. (2014) "Turning on caspases with genetics and small molecules." Methods Enzymol. 2014;544:179-213

15. Wiita A.P., Ziv E., Wiita P.J., Urisman A., Julien O., Burlingame A.L., Weissman J.S., and Wells J.A. (2013) "Global cellular response to chemotherapy-induced apoptosis." eLife. 2:e01236

14. Crawford E.D., Seaman J.E., Agard N., Hsu G.W., Julien O., Mahrus S., Nguyen H., Shimbo K., Yoshihara H., Zhuang M., Chalkley R.J., Wells J.A. (2013) "The DegraBase: a database of proteolysis in healthy and apoptotic human cells." Mol. Cell. Proteomics 12, 813-824

Ph.D. and earlier work

13. Lee D., Kraus A., Groenendyk J., Prins D., Liu W.-X., Li H.-D., Julien O., Touret N., Sykes B. and Michalak M. (2015) "UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum." J. Biol. Chem. 290:5725-5738.

12. Pineda Sanabria S.E., Julien O., Sykes B.D. (2014) "A versatile cardiac troponin chimera for muscle protein structural biology and drug discovery." ACS Chem. Biol. 9:2121-2130.

11. Julien O., Wang G., Jonckheer A., Engelborghs Y., and Sykes B. D. (2012) "Tryptophan side chain conformers monitored by NMR and time-resolved fluorescence spectroscopies." Proteins: Structure, Function, and Bioinformatics. 80(1):239-245.

10. Julien O., Chatterjee S., Bjorndahl T.C., Sweeting B., Acharya S., Semenchenko V., Chakrabartty A., Pai E.F, Wishart D.S., Sykes B.D. and Cashman N.R. (2011) "Relative and Regional Stabilities of the Hamster, Mouse, Rabbit, and Bovine Prion Proteins toward Urea Unfolding Assessed by Nuclear Magnetic Resonance and Circular Dichroism Spectroscopies." Biochemistry. 50(35):7536-7545.

9. Julien O., Mercier P., Allen C., Fisette O., Ramos C.H., Lagüe P., Blumenschein T.M.A., and Sykes B.D. (2011) "Is There Nascent Structure in the Intrinsically Disordered Region of Troponin I?" Proteins: Structure, Function, and Bioinformatics. 79(4):1240-1250.

8. Julien O., Beadle J.R., Magee W.C., Chatterjee S., Hostetler K.Y., Evans D.H., Sykes B.D. (2011) "Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir." Journal of the American Chemical Society. 133(7):2264-2274.

7. Julien O., Graether S.P., Sykes B.D. (2009) "Monitoring prion protein stability by NMR." Journal of Toxicology and Environmental Health.

6. Julien O., Chatterjee S., Graether S. P., Thiessen A., Sykes B. D. (2009) "Differential stability of the bovine prion protein upon urea unfolding." Protein Science. 18:2172-2182.

5. Julien O., Mercier P., Crane M. L., Sykes B. D. (2009) "The effect of the co-solvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C." Protein Science. 18:1165-1174.

4. Julien O., Mercier P., Spyracopoulos L., Corrie J.E.T., Sykes B.D. (2008) "NMR Studies of the Dynamics of a Bifunctional Rhodamine Probe Attached to Troponin C." Journal of the American Chemical Society. 130:2602-2609

3. Julien O., Sun Y.-B, Wang X., Lindhout D. A., Thiessen A., Irving M., Sykes B.D. (2008) "Tryptophan Mutants of Cardiac Troponin C: Correlation Between 3D Structure, Troponin I Affinity, and in situ Activity." Biochemistry. 47:597-606.

2. Julien O., Sun Y.-B., Knowles A.C., Brandmeier B.D., Dale R.E., Trentham D.R., Corrie J.E.T., Sykes B.D., Irving M. (2007) "Towards Protein Structure in situ: Comparison of Two Bifunctional Rhodamine Adducts of Troponin C." Biophysical Journal. 93:1008-1020

1. Julien O., Gignac I., Hutton A., Yee A., Arrowsmith C.H., Gagné S.M. (2006) "MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like Repeats." J. Biomol. NMR. 35:149-154.